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Bioscience Horizons Advance Access published online on April 22, 2008
Bioscience Horizons, doi:10.1093/biohorizons/hzn020
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© Oxford University Press 2008

The role of hepatitis C virus in the pathogenesis of hepatocellular carcinoma

Gui Tran*

Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK

* Corresponding author: 19 Cambridge Street, Derby DE23 8HG, UK. Tel: +44 7793531066. Email address: guitran{at}gmail.com

Supervisor: Professor Mark Harris, University of Leeds, Leeds, UK.


  Abstract

Hepatitis C virus (HCV) is a worldwide pandemic, chronically affecting over 170 million people worldwide. It is a major risk factor for the development of hepatocellular carcinoma (HCC) and there is increasing experimental evidence to suggest that the virus plays a direct role in neoplastic transformation. The purpose of this letter is to review the literature regarding two individual proteins of HCV, namely NS5A and core, and their role in the pathogenesis of HCC through perturbations of cellular pathways, in addition to their immunopathological effects of chronic inflammation. A systematic search of MEDLINE in addition to manual searches of citations in key papers was employed to identify relevant studies. There is overwhelming evidence suggesting the direct and indirect roles HCV plays in the pathogenesis of HCC. Recent progress in our understanding of the pathophysiology of HCV coupled with advances in in vitro models will ensure that positive strides are made in the treatment and management of this potentially fatal virus.

Key words: Hepatitis C, hepatocellular carcinoma, core, NS5A

Submitted on 29 September 2007; accepted on 5 March 2008


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